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From The Collaborative International Dictionary of English v.0.48:
Ghetto \Ghet"to\, n. [It.] A quarter of a city where Jews live in greatest numbers. [Webster 1913 Suppl.] I went to the Ghetto, where the Jews dwell. --Evelyn. [Webster 1913 Suppl.] 2. By extension: Any section of a town inhabited predominantly by members of a specific ethnic, national or racial group, such segregation usually arising from social or economic pressure. The term is commonly applied to areas in cities having a high concentration of low-income African-Americans. [PJC] 3. [fig.] Any isolated group of people. [PJC] 4. [fig.] Any group isolated by external pressures, with an implication of inferiority. [PJC]