From The Collaborative International Dictionary of English v.0.48:

Nazarene \Naz`a*rene"\, prop. n. [L. Nazarenus, Gr. ?, fr. ?
   1. A native or inhabitant of Nazareth; -- a term of contempt
      applied to Christ and the early Christians.
      [1913 Webster]

   2. (Eccl. Hist.) One of a sect of Judaizing Christians in the
      first and second centuries, who observed the laws of
      Moses, and held to certain heresies.
      [1913 Webster]
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