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From The Collaborative International Dictionary of English v.0.48:
Nazarene \Naz`a*rene"\, prop. n. [L. Nazarenus, Gr. ?, fr. ? Nazareth.] 1. A native or inhabitant of Nazareth; -- a term of contempt applied to Christ and the early Christians. [1913 Webster] 2. (Eccl. Hist.) One of a sect of Judaizing Christians in the first and second centuries, who observed the laws of Moses, and held to certain heresies. [1913 Webster]