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From The Collaborative International Dictionary of English v.0.48:
Noisome \Noi"some\, a. [For noysome, fr. noy for annoy. See Annoy.] 1. Noxious to health; hurtful; mischievous; unwholesome; insalubrious; destructive; as, noisome effluvia. "Noisome pestilence." --Ps. xci. 3. [1913 Webster] 2. Offensive to the smell or other senses; disgusting; fetid. "Foul breath is noisome." --Shak. [1913 Webster] -- Noi"some*ly, adv. -- Noi"some*ness, n. [1913 Webster] Syn: Noxious; unwholesome; insalubrious; mischievous; destructive. Usage: Noisome, Noxious. These words have to a great extent been interchanged; but there is a tendency to make a distinction between them, applying noxious to things that inflict evil directly; as, a noxious plant, noxious practices, etc., and noisome to things that operate with a remoter influence; as, noisome vapors, a noisome pestilence, etc. Noisome has the additional sense of disqusting. A garden may be free from noxious weeds or animals; but, if recently covered with manure, it may be filled with a noisome smell. [1913 Webster]