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From The Collaborative International Dictionary of English v.0.48:
Orthopnoea \Or`thop*n[oe]"a\, Orthopny \Or*thop"ny\, n. [L. orthopnoea, Gr. ?; 'orqo`sstraight, right + pnei^n to breathe: cf. F. orthopn['e]e.] (Med.) Specifically, a morbid condition in which respiration can be performed only in an erect posture; by extension, any difficulty of breathing. [1913 Webster]