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From The Collaborative International Dictionary of English v.0.48:
Vixen \Vix"en\, n. [AS. fixen a she-fox, for fyxen, fem. of fox. See Fox.] 1. A female fox. [Obs. or Prov. Eng.] [1913 Webster] 2. A cross, ill-tempered person; -- formerly used of either sex, now only of a woman. --Barrow. [1913 Webster] She was a vixen when she went to school. --Shak. [1913 Webster]