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From The Collaborative International Dictionary of English v.0.48:
Wanion \Wan"ion\, n. [Probably for OE. waniand waning, p. pr. of wanien; hence, used of the waning of the moon, supposed to be an unlucky time. See Wane.] A word of uncertain signification, used only in the phrase with a wanion, apparently equivalent to with a vengeance, with a plague, or with misfortune. [Obs.] --B. Jonson. Latimer. [1913 Webster]