it is all up with him

From The Collaborative International Dictionary of English v.0.48:

Up \Up\ ([u^]p), adv. [AS. up, upp, [=u]p; akin to OFries. up,
   op, D. op, OS. [=u]p, OHG. [=u]f, G. auf, Icel. & Sw. upp,
   Dan. op, Goth. iup, and probably to E. over. See Over.]
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   1. Aloft; on high; in a direction contrary to that of
      gravity; toward or in a higher place or position; above;
      -- the opposite of down.
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            But up or down,
            By center or eccentric, hard to tell. --Milton.
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   2. Hence, in many derived uses, specifically: 
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      (a) From a lower to a higher position, literally or
          figuratively; as, from a recumbent or sitting
          position; from the mouth, toward the source, of a
          river; from a dependent or inferior condition; from
          concealment; from younger age; from a quiet state, or
          the like; -- used with verbs of motion expressed or
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                But they presumed to go up unto the hilltop.
                                                  --Num. xiv.
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                I am afflicted and ready to die from my youth
                up.                               --Ps.
                                                  lxxxviii. 15.
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                Up rose the sun, and up rose Emelye. --Chaucer.
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                We have wrought ourselves up into this degree of
                Christian indifference.           --Atterbury.
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      (b) In a higher place or position, literally or
          figuratively; in the state of having arisen; in an
          upright, or nearly upright, position; standing;
          mounted on a horse; in a condition of elevation,
          prominence, advance, proficiency, excitement,
          insurrection, or the like; -- used with verbs of rest,
          situation, condition, and the like; as, to be up on a
          hill; the lid of the box was up; prices are up.
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                And when the sun was up, they were scorched.
                                                  --Matt. xiii.
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                Those that were up themselves kept others low.
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                Helen was up -- was she?          --Shak.
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                Rebels there are up,
                And put the Englishmen unto the sword. --Shak.
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                His name was up through all the adjoining
                provinces, even to Italy and Rome; many desiring
                to see who he was that could withstand so many
                years the Roman puissance.        --Milton.
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                Thou hast fired me; my soul's up in arms.
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                Grief and passion are like floods raised in
                little brooks by a sudden rain; they are quickly
                up.                               --Dryden.
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                A general whisper ran among the country people,
                that Sir Roger was up.            --Addison.
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                Let us, then, be up and doing,
                With a heart for any fate.        --Longfellow.
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      (c) To or in a position of equal advance or equality; not
          short of, back of, less advanced than, away from, or
          the like; -- usually followed by to or with; as, to be
          up to the chin in water; to come up with one's
          companions; to come up with the enemy; to live up to
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                As a boar was whetting his teeth, up comes a fox
                to him.                           --L'Estrange.
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      (d) To or in a state of completion; completely; wholly;
          quite; as, in the phrases to eat up; to drink up; to
          burn up; to sum up; etc.; to shut up the eyes or the
          mouth; to sew up a rent.
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   Note: Some phrases of this kind are now obsolete; as, to
         spend up (--Prov. xxi. 20); to kill up (--B. Jonson).
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      (e) Aside, so as not to be in use; as, to lay up riches;
          put up your weapons.
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   Note: Up is used elliptically for get up, rouse up, etc.,
         expressing a command or exhortation. "Up, and let us be
         going." --Judg. xix. 28.
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               Up, up, my friend! and quit your books,
               Or surely you 'll grow double.     --Wordsworth.
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   It is all up with him, it is all over with him; he is lost.

   The time is up, the allotted time is past.

   To be up in, to be informed about; to be versed in.
      "Anxious that their sons should be well up in the
      superstitions of two thousand years ago." --H. Spencer.

   To be up to.
      (a) To be equal to, or prepared for; as, he is up to the
          business, or the emergency. [Colloq.]
      (b) To be engaged in; to purpose, with the idea of doing
          ill or mischief; as, I don't know what he's up to.

   To blow up.
      (a) To inflate; to distend.
      (b) To destroy by an explosion from beneath.
      (c) To explode; as, the boiler blew up.
      (d) To reprove angrily; to scold. [Slang]

   To bring up. See under Bring, v. t.

   To come up with. See under Come, v. i.

   To cut up. See under Cut, v. t. & i.

   To draw up. See under Draw, v. t.

   To grow up, to grow to maturity.

   Up anchor (Naut.), the order to man the windlass
      preparatory to hauling up the anchor.

   Up and down.
      (a) First up, and then down; from one state or position to
          another. See under Down, adv.

                Fortune . . . led him up and down. --Chaucer.
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      (b) (Naut.) Vertical; perpendicular; -- said of the cable
          when the anchor is under, or nearly under, the hawse
          hole, and the cable is taut. --Totten.

   Up helm (Naut.), the order given to move the tiller toward
      the upper, or windward, side of a vessel.

   Up to snuff. See under Snuff. [Slang]

   What is up? What is going on? [Slang]
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