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From The Collaborative International Dictionary of English v.0.48:
Mule \Mule\ (m[=u]l), n. [F., a she-mule, L. mula, fem. of mulus; cf. Gr. my`klos, mychlo`s. Cf. AS. m[=u]l, fr. L. mulus. Cf. Mulatto.] 1. (Zool.) A hybrid animal; specifically, one generated between an ass and a mare. Sometimes the term is applied to the offspring of a horse and a she-ass, but that hybrid is more properly termed a hinny. See Hinny. [1913 Webster] Note: Mules are much used as draught animals. They are hardy, and proverbial for stubbornness. [1913 Webster] 2. (Bot.) A plant or vegetable produced by impregnating the pistil of one species with the pollen or fecundating dust of another; -- called also hybrid. [1913 Webster] 3. A very stubborn person. [1913 Webster] 4. A machine, used in factories, for spinning cotton, wool, etc., into yarn or thread and winding it into cops; -- called also jenny and mule-jenny. [1913 Webster] 5. A slipper that has no fitting around the heel. Syn: mules, scuff, scuffs. [WordNet 1.5] Mule armadillo (Zool.), a long-eared armadillo (Tatusia hybrida), native of Buenos Ayres; -- called also mulita. See Illust. under Armadillo. Mule deer (Zool.), a large deer (Cervus macrotis syn. Cariacus macrotis) of the Western United States. The name refers to its long ears. Mule pulley (Mach.), an idle pulley for guiding a belt which transmits motion between shafts that are not parallel. Mule twist, cotton yarn in cops, as spun on a mule; -- in distinction from yarn spun on a throstle frame. [1913 Webster]