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softening of the brain
From The Collaborative International Dictionary of English v.0.48:
Softening \Sof"ten*ing\, a. & n. from Soften, v. [1913 Webster] Softening of the brain, or Cerebral softening (Med.), a localized softening of the brain substance, due to hemorrhage or inflammation. Three varieties, distinguished by their color and representing different stages of the morbid process, are known respectively as red, yellow, and white, softening. [1913 Webster]