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ups and downs
From The Collaborative International Dictionary of English v.0.48:
Up \Up\, n. The state of being up or above; a state of elevation, prosperity, or the like; -- rarely occurring except in the phrase ups and downs. [Colloq.] [1913 Webster] Ups and downs, alternate states of elevation and depression, or of prosperity and the contrary. [Colloq.] [1913 Webster] They had their ups and downs of fortune. --Thackeray. [1913 Webster]