From The Collaborative International Dictionary of English v.0.48:

Vixen \Vix"en\, n. [AS. fixen a she-fox, for fyxen, fem. of fox.
   See Fox.]
   1. A female fox. [Obs. or Prov. Eng.]
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   2. A cross, ill-tempered person; -- formerly used of either
      sex, now only of a woman. --Barrow.
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            She was a vixen when she went to school. --Shak.
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